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The fission yeast SPB component Dms1 is required to initiate forespore membrane formation and maintain meiotic SPB components
https://ocu-omu.repo.nii.ac.jp/records/2020443
https://ocu-omu.repo.nii.ac.jp/records/2020443180c078e-60c7-4f8b-a6d1-e180f1b478e4
| 名前 / ファイル | ライセンス | アクション |
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本文 (10.0 MB)
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| Item type | 共通(1) | |||||||||||||||||
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| 公開日 | 2018-11-20 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | The fission yeast SPB component Dms1 is required to initiate forespore membrane formation and maintain meiotic SPB components | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 作成者 |
新美, 柊子
× 新美, 柊子
× 中村, 太郎
KAKEN2
1000030291082
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| 権利情報 | ||||||||||||||||||
| 言語 | ja | |||||||||||||||||
| 権利情報Resource | https://creativecommons.org/licenses/by/4.0/ | |||||||||||||||||
| 権利情報 | クリエイティブ・コモンズ 表示 4.0 国際 | |||||||||||||||||
| 権利情報 | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 権利情報Resource | https://creativecommons.org/licenses/by/4.0/ | |||||||||||||||||
| 権利情報 | Creative Commons Attribution 4.0 International | |||||||||||||||||
| 権利情報 | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 権利情報 | © 2018 Niimi, Nakamura. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||||||||||||||
| 内容記述 | ||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | The spindle pole body (SPB) plays a central role in spore plasma membrane formation in addition to its recognized role in microtubule organization. During meiosis, a biomembrane called the forespore membrane (FSM) is newly formed at the SPB. Although several SPB proteins essential for the initiation of FSM formation (meiotic SPB components) have been identified, the molecular mechanism is still unknown. Here, we report the isolation and functional characterization of Dms1 as a component of the SPB. We show that FSM formation does not initiate in dms1Δ cells. Dms1 protein is constitutively expressed throughout the life cycle and localizes to the SPB and the nuclear envelope. The predicted Dms1 protein has a transmembrane domain, which is required for correct localization at the SPB. Dms1 is essential for the proper localization of three meiotic SPB components, Spo15, Spo2, and Spo13, but these components do not affect localization of Dms1. Collectively, these results suggest that Dms1 anchors these meiotic SPB components to the SPB, thereby facilitating the initiation of FSM formation. | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 内容記述 | ||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||
| 内容記述 | This study was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan to T. Nakamura (#15K07057 and #18K06225) (https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15K07057/; https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-18K06225/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | Public Library of Science | |||||||||||||||||
| 言語 | en | |||||||||||||||||
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| 言語 | eng | |||||||||||||||||
| 記事種別等 | ||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||
| 内容記述 | Research Article | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
| 識別子 | ||||||||||||||||||
| 識別子 | https://doi.org/10.1371/journal.pone.0197879 | |||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||
| 書誌情報 |
en : PLOS ONE 巻 13, 号 5, p. e0197879, 発行日 2018-05-29 |
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| 収録物識別子 | ||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 1932-6203 | |||||||||||||||||
