| Item type |
共通(1) |
| 公開日 |
2019-01-16 |
| タイトル |
|
|
タイトル |
Association between the Left Atrial Emptying Fraction and Silent Brain Infarction in Patients with Paroxysmal Atrial Fibrillation |
|
言語 |
en |
| 作成者 |
河相, 優
杉岡, 憲一
岩田, 真一
坂本, 真一
石川, 世良
高木, 雅彦
三木, 幸雄
葭山, 稔
|
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This article may be downloaded for personal use only. Any other use requires prior permission of the author and Osaka City Medical Association. |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Paroxysmal atrial fibrillation |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Silent brain infarction |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Echocardiography |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Left atrial emptying fraction |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background : Patients with atrial fibrillation (AF) often show a high prevalence of silent brain infarction (SBI), which is an independent risk factor for the development of symptomatic stroke. The left atrial emptying fraction (LAEF) is also known to be associated with an increased risk of symptomatic stroke in patients with AF; however, little is known regarding the association between SBI and LAEF in patients with paroxysmal AF. / Methods : We investigated 77 neurologically asymptomatic patients with paroxysmal AF (56 men, median age 66 years) who were scheduled to undergo transcatheter pulmonary vein isolation or electrical cardioversion. All patients underwent brain magnetic resonance imaging to screen for SBI prior to the scheduled ablation or cardioversion. Comprehensive transthoracic echocardiography was performed to calculate the LAEF. / Results : SBI was observed in 21 patients (27%). Univariate analysis showed a negative association between LAEF and SBI [odds ratio (OR) 0.92, 95% confidence interval (CI) 0.87-0.98, p=0.005]. Receiver operating characteristic curve analysis indicated that the optimal cut-off value for SBI (area under the curve 0.70) was 45.5% with a sensitivity of 62% and a specificity of 79%. Multivariate logistic regression analysis indicated that LAEF <45.5% remained independently associated with SBI (OR 6.35, 95% CI 1.82-22.1, p=0.004) after adjusting for the CHA_2DS_2-VASc score and the estimated glomerular filtration rate. / Conclusions : An impaired LAEF is associated with SBI in patients with paroxysmal AF and might be a useful parameter for risk stratification. Intensive intervention in high-risk patients may avoid SBI and reduce the subsequent stroke risk. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
OSAKA CITY MEDICAL ASSOCIATION |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
NCID |
|
|
関連識別子 |
AA00765896 |
| 書誌情報 |
en : Osaka City Medical Journal
巻 64,
号 2,
p. 121-130,
発行日 2018-12
|
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0030-6096 |
本文 (1.5 MB)
