| Item type |
共通(1) |
| 公開日 |
2017-12-18 |
| タイトル |
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タイトル |
Passive immunotherapy of tauopathy targeting pSer413-tau : a pilot study in mice |
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言語 |
en |
| 作成者 |
梅田, 知宙
江口, 広志
| en |
Eguchi, Hiroshi
Teijin Institute for Bio-medical Research, Teijin Pharma Limited
|
| ja-Kana |
エグチ, ヒロシ
|
| ja |
江口, 広志
|
Search repository
九里, 裕一
| en |
Kunori, Yuichi
Teijin Institute for Bio-medical Research, Teijin Pharma Limited
|
| ja-Kana |
クノリ, ユウイチ
|
| ja |
九里, 裕一
|
Search repository
松本, 洋一
| en |
Matsumoto, Yoichi
Teijin Institute for Bio-medical Research, Teijin Pharma Limited
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| ja-Kana |
マツモト, ヨウイチ
|
| ja |
松本, 洋一
|
Search repository
谷口, 泰造
森, 啓
富山, 貴美
|
| 権利情報 |
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言語 |
ja |
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権利情報Resource |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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権利情報 |
クリエイティブ・コモンズ 表示 - 非営利 - 改変禁止 4.0 国際 |
| 権利情報 |
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言語 |
en |
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権利情報Resource |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
権利情報 |
Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International |
| 権利情報 |
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|
言語 |
en |
|
権利情報 |
© 2015 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. |
| 内容記述 |
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内容記述タイプ |
Abstract |
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内容記述 |
Objective: Cellular inclusions of hyperphosphorylated tau are a hallmark of tauopathies, which are neurodegenerative disorders that include Alzheimer's disease (AD). Active and passive immunization against hyperphosphorylated tau has been shown to attenuate phenotypes in model mice. We developed new monoclonal antibodies to hyperphosphorylated tau and sought high therapeutic efficacy for future clinical use. / Methods: Using more than 20 antibodies, we investigated which sites on tau are phosphorylated early and highly in the tauopathy mouse models tau609 and tau784. These mice display tau hyperphosphorylation, synapse loss, memory impairment at 6 months, and tangle formation and neuronal loss at 15 months. We generated mouse monoclonal antibodies to selected epitopes and examined their effects on memory and tau pathology in aged tau609 and tau784 mice by the Morris water maze and by histological and biochemical analyses.... |
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言語 |
en |
| 出版者 |
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出版者 |
Wiley |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 記事種別等 |
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内容記述タイプ |
Other |
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内容記述 |
Research Article |
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言語 |
en |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版タイプ |
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|
出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 識別子 |
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|
識別子 |
https://doi.org/10.1002/acn3.171 |
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識別子タイプ |
DOI |
| 書誌情報 |
en : Annals of Clinical and Translational Neurology
巻 2,
号 3,
p. 241-255,
発行日 2015-03
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| 収録物識別子 |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2328-9503 |
本文 (1.2 MB)
