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After it is published, it will be found at https://doi.org/10.1177/2050640618791053 . Masaru Enomoto, Yoshihiro Ikura, Akihiro Tamori,et al., Short-term histological evaluations after achieving a sustained virologic response to direct-acting antiviral treatment for chronic hepatitis C, United European Gastroenterology Journal, Vol 6, Issue 9, pp.1391-1400. Copyright ©Authors 2018. Reprinted by permission of SAGE Publications","subitem_rights_language":"en"}]},"item_1617186609386":{"attribute_name":"主題","attribute_value_mlt":[{"subitem_subject":"直接作動型抗ウイルス薬","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"C型肝炎ウイルス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Biopsy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"direct-acting antiviral","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hepatitis C virus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"histology","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"sustained virologic response","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"【概要】C型慢性肝炎に対するDAA治療後の肝病理組織所見の検討は、これまで十分になされていませんでした。本研究ではDAA治療によってウイルス排除に成功し、かつ血液検査で異常が見られなかった51症例に対し肝生検を行い、炎症、線維化、鉄沈着、脂肪化などの項目について調べました。その結果、ほとんどの症例で肝組織の改善が見られました。また、同時に約2割程度の症例に有意な炎症が残存していることがわかりました。DAAによってC型肝炎ウイルスを排除することにより、血液検査のみならず肝生検結果の改善も見られたことから、治療によって将来的には肝硬変や肝臓がんへの進展が予防できることが期待されます。一方、炎症が残存していた症例の少なくとも一部は脂肪肝炎が原因であったことから、治療後もアルコール多飲や肥満などを避けて生活習慣に注意する必要があると考えられます。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Background: Interferon-free, direct-acting antiviral (DAA) treatments can result in a sustained virologic response (SVR) in nearly 100% of patients with chronic hepatitis C virus (HCV) infection. / Aims: To evaluate histological improvement after achieving an SVR to DAA treatments in patients with chronic hepatitis C. / Methods: Among 691 patients with chronic hepatitis C who achieved an SVR to DAAs, 51 underwent liver biopsy 41 ± 20 weeks after the end of treatment despite normal transaminase levels. In 20 patients, liver biopsy specimens obtained a median of 1.2 years before the start of treatment were available....","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"This work was supported in part by JSPS KAKENHI (Grant Number 16K09369).","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"SAGE Publishing","subitem_publisher_language":"en"}]},"item_1617186783814":{"attribute_name":"識別子","attribute_value_mlt":[{"subitem_identifier_type":"DOI","subitem_identifier_uri":"https://doi.org/10.1177/2050640618791053"}]},"item_1617186920753":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"2050-6414","subitem_source_identifier_type":"ISSN"}]},"item_1617187056579":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-11-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"1400","bibliographicPageStart":"1391","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"United European Gastroenterology Journal","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_b1a7d7d4d402bcce","subitem_version_type":"AO"}]},"item_1617353299429":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1177/2050640618791053","subitem_relation_type_select":"DOI"}}]},"item_1722232185104":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-11-02"}],"displaytype":"detail","filename":"20506414-6-9-1391.pdf","filesize":[{"value":"2.5 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://ocu-omu.repo.nii.ac.jp/record/2020542/files/20506414-6-9-1391.pdf"},"version_id":"1bbb0ca4-8092-4557-91bf-6ea98671f71a"}]},"item_1722577087681":{"attribute_name":"記事種別等","attribute_value_mlt":[{"subitem_description":"Full Article","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_1725590125188":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_title":"Short-term histological evaluations after achieving a sustained virologic response to direct-acting antiviral treatment for chronic hepatitis C","item_type_id":"40002","owner":"7","path":["1721355153493"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-11-02"},"publish_date":"2018-11-02","publish_status":"0","recid":"2020542","relation_version_is_last":true,"title":["Short-term histological evaluations after achieving a sustained virologic response to direct-acting antiviral treatment for chronic hepatitis C"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-31T02:50:28.137080+00:00"}