{"created":"2024-10-31T02:48:42.158828+00:00","id":2020522,"links":{},"metadata":{"_buckets":{"deposit":"532f022d-1de3-4443-855c-089272ed5170"},"_deposit":{"created_by":7,"id":"2020522","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2020522"},"status":"published"},"_oai":{"id":"oai:ocu-omu.repo.nii.ac.jp:02020522","sets":["1623632832836:1721355153493"]},"author_link":[],"item_1617186331708":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Heated Tobacco Products Impair Cell Viability, Osteoblastic Differentiation, and Bone Fracture-Healing","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Nishino, Kazuya","creatorNameLang":"en"},{"creatorName":"ニシノ, カズヤ","creatorNameLang":"ja-Kana"},{"creatorName":"西野, 壱哉","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"nrid/1000080967406","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/nrid/1000080967406/"},{"nameIdentifier":"0000-0003-2454-2771","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0003-2454-2771"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Tamai, Koji","creatorNameLang":"en"},{"creatorName":"タマイ, コウジ","creatorNameLang":"ja-Kana"},{"creatorName":"玉井, 孝司","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1000030711824","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000030711824"},{"nameIdentifier":"0000-0003-1467-2599","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0003-1467-2599"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Orita, Kumi","creatorNameLang":"en"},{"creatorName":"オリタ, クミ","creatorNameLang":"ja-Kana"},{"creatorName":"折田, 久美","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1000040748597","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000040748597"},{"nameIdentifier":"0000-0003-3291-2509","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0003-3291-2509"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Hashimoto, Yusuke","creatorNameLang":"en"},{"creatorName":"ハシモト, ユウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"橋本, 祐介","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1000010382178","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000010382178"},{"nameIdentifier":"0000-0001-8138-5341","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0001-8138-5341"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Nakamura, Hiroaki","creatorNameLang":"en"},{"creatorName":"ナカムラ, ヒロアキ","creatorNameLang":"ja-Kana"},{"creatorName":"中村, 博亮","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1000060227931","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000060227931"},{"nameIdentifier":"0000-0002-5380-5000","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0002-5380-5000"}]}]},"item_1617186499011":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"The following article has been accepted by Journal of Bone & Joint Surgery. This is the accepted manuscript version. For personal use only. The final, published version is available at https://doi.org/10.2106/JBJS.20.02227.","subitem_rights_language":"en"}]},"item_1617186609386":{"attribute_name":"主題","attribute_value_mlt":[{"subitem_subject":"加熱式タバコ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"アルカリフォスファターゼ活性","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ALP","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究グループは、近年国内でも爆発的に普及している加熱式タバコが燃焼式タバコと同様に細胞生存率を低下させ、骨分化、骨癒合の阻害をもたらすことを明らかにしました。燃焼式タバコの骨癒合への悪影響については広く知られていますが、加熱式タバコは体へ及ぼす害が少ないと一部では信じられています。そこで、本研究グループは加熱式タバコが骨癒合に与える影響を基礎的研究にて明らかにすることを目的に、燃焼式、加熱式でそれぞれタバコ抽出液を作成して前骨芽細胞に投与し、細胞生存率と骨分化誘導条件下における阻害作用を評価しました。また、ラットの大腿骨骨切りモデルに対しても各々の抽出液を投与し、4週間後に骨組成、仮骨体積と力学強度を測定しました。その結果、細胞生存率は両群共に時間、濃度に依存して有意に低下しました。骨分化モデルでは、両群ともにALP活性が対照群より有意に低く、動物実験では、骨塩量、仮骨体積、また力学試験における最大荷重、弾性率が両群共に対照の抽出液を投与しない群より有意に低下しました。本研究結果から、骨折治療中や骨癒合を必要とする手術に際しては燃焼式タバコだけではなく加熱式タバコの禁煙も勧めるべきであると考えられます。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Background: The negative impact of cigarette smoking on bone union has been well documented. However, the impact of heated tobacco product (HTP) use on bone fracture-healing remains unclear. The present study investigated the effect of HTPs on preosteoblast viability, osteoblastic differentiation, and fracture-healing and compared the effects with those of conventional combustible cigarettes. ...","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"The present study was supported by a Grant-in-Aid for Scientific Research (Grant Number: 19K09604), which was provided by the Ministry of Education, Culture, Sports, Science and Technology of the Japanese government.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Lippincott, Williams & Wilkins","subitem_publisher_language":"en"}]},"item_1617186783814":{"attribute_name":"識別子","attribute_value_mlt":[{"subitem_identifier_type":"DOI","subitem_identifier_uri":"https://doi.org/10.2106/JBJS.20.02227"}]},"item_1617186920753":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"1535-1386","subitem_source_identifier_type":"ISSN"}]},"item_1617187056579":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-11-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"21","bibliographicPageEnd":"2031","bibliographicPageStart":"2024","bibliographicVolumeNumber":"103","bibliographic_titles":[{"bibliographic_title":"The Journal of Bone and Joint Surgery","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_b1a7d7d4d402bcce","subitem_version_type":"AO"}]},"item_1617353299429":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2106/JBJS.20.02227","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"AA12750309","subitem_relation_type_select":"NCID"}}]},"item_1722232185104":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-11-02"}],"displaytype":"detail","filename":"15351386-103-21-2024.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://ocu-omu.repo.nii.ac.jp/record/2020522/files/15351386-103-21-2024.pdf"},"version_id":"297ed08b-1c6d-4f8a-af0f-fe4efdf21636"}]},"item_1722577087681":{"attribute_name":"記事種別等","attribute_value_mlt":[{"subitem_description":"Scientific Article","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_1725590125188":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_title":"Heated Tobacco Products Impair Cell Viability, Osteoblastic Differentiation, and Bone Fracture-Healing","item_type_id":"40002","owner":"7","path":["1721355153493"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-11-02"},"publish_date":"2022-11-02","publish_status":"0","recid":"2020522","relation_version_is_last":true,"title":["Heated Tobacco Products Impair Cell Viability, Osteoblastic Differentiation, and Bone Fracture-Healing"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-31T02:48:50.362103+00:00"}