{"created":"2024-10-31T02:38:13.089532+00:00","id":2020470,"links":{},"metadata":{"_buckets":{"deposit":"b92eee1c-d0b9-465b-944e-a5783aa6f25d"},"_deposit":{"created_by":7,"id":"2020470","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2020470"},"status":"published"},"_oai":{"id":"oai:ocu-omu.repo.nii.ac.jp:02020470","sets":["1623632832836:1721355153493"]},"author_link":[],"item_1617186331708":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Robust information routing by dorsal subiculum neurons","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University, Japan Science and Technology Agency","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Kitanishi, Takuma","creatorNameLang":"en"},{"creatorName":"キタニシ, タクマ","creatorNameLang":"ja-Kana"},{"creatorName":"北西, 卓磨","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1000090722116","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000090722116"},{"nameIdentifier":"0000-0001-8062-3854","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0001-8062-3854"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Umaba, Ryoko","creatorNameLang":"en"},{"creatorName":"ウマバ, リョウコ","creatorNameLang":"ja-Kana"},{"creatorName":"馬場, 良子","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Mizuseki, Kenji","creatorNameLang":"en"},{"creatorName":"ミズセキ, ケンジ","creatorNameLang":"ja-Kana"},{"creatorName":"水関, 健司","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1000080344448","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000080344448"},{"nameIdentifier":"0000-0002-1456-2149","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0002-1456-2149"}]}]},"item_1617186499011":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"クリエイティブ・コモンズ　表示 - 非営利 4.0 国際","subitem_rights_language":"ja","subitem_rights_resource":"https://creativecommons.org/licenses/by-nc/4.0/ "},{"subitem_rights":"Creative Commons Attribution-NonCommercial 4.0 International","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by-nc/4.0/ "},{"subitem_rights":"© 2021 Author(s). ","subitem_rights_language":"en"}]},"item_1617186626617":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究グループは、さまざまな空間情報が海馬から海馬台を経て下流の4箇所の脳領域(側坐核・視床・乳頭体・帯状皮質)へと分配される脳情報の流れを世界で初めて明らかにしました。空間認識に関わる情報は海馬で処理され、海馬で処理された情報は他の脳領域へと伝達され活用されることで脳機能を支えると考えられていますが、どのように分配・伝達されるかはこれまで不明でした。そこで本研究では、ラットの海馬台において、情報の伝達先を網羅的に同定しつつ神経活動を計測する大規模電気生理学解析を行いました。その結果、海馬台は、海馬に比べてノイズに強い頑健な情報表現を持つことを見いだしました。さらに、「移動スピード」と「道順」の情報はそれぞれ帯状皮質と側坐核に選択的に伝達され、「場所」の情報は側坐核・視床・乳頭体・帯状皮質の4領域に均等に分配されることを明らかにしました。これは、海馬台から下流の脳領域への情報分配の様式を明らかにした世界初の成果で、海馬を中心とした記憶システムの動作原理の解明や、認知症における記憶力低下の病態の理解につながることが期待されます。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"The dorsal hippocampus conveys various information associated with spatial navigation; however, how the information is distributed to multiple downstream areas remains unknown. We investigated this by identifying axonal projections using optogenetics during large-scale recordings from the rat subiculum, the major hippocampal output structure. Subicular neurons demonstrated a noise-resistant representation of place, speed, and trajectory, which was as accurate as or even more accurate than that of hippocampal CA1 neurons....","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"本研究は、科学技術振興機構戦略的創造研究推進事業さきがけ(JPMJPR1882)、科学研究費補助金(20H03356, 19H05225, 18H05137, 17K19462, 16H04656, 16H01279, 20K06878, 19H04937, 17H05977, 17H05575)、東レ科学振興会、武田科学振興財団、上原記念生命科学財団、内藤記念科学振興財団、中島記念国際交流財団、住友電工グループ社会貢献基金、ライフサイエンス振興財団、ブレインサイエンス振興財団、島津科学技術振興財団、ノバルティス科学振興財団、大阪市立大学戦略的研究の対象研究です。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Association for the Advancement of Science","subitem_publisher_language":"en"}]},"item_1617186783814":{"attribute_name":"識別子","attribute_value_mlt":[{"subitem_identifier_type":"DOI","subitem_identifier_uri":"https://doi.org/10.1126/sciadv.abf1913"}]},"item_1617186920753":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"2375-2548","subitem_source_identifier_type":"ISSN"}]},"item_1617187056579":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-03-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageStart":"eabf1913","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"Science Advances","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1722232185104":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-03-18"}],"displaytype":"detail","filename":"23752548-7-11-eabf1913.pdf","filesize":[{"value":"4.1 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://ocu-omu.repo.nii.ac.jp/record/2020470/files/23752548-7-11-eabf1913.pdf"},"version_id":"8475c7f8-1e0c-4b9b-918b-a2b658ab2ee9"}]},"item_1722577087681":{"attribute_name":"記事種別等","attribute_value_mlt":[{"subitem_description":"RESEARCH ARTICLE","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_1725590125188":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_title":"Robust information routing by dorsal subiculum neurons","item_type_id":"40002","owner":"7","path":["1721355153493"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-03-18"},"publish_date":"2021-03-18","publish_status":"0","recid":"2020470","relation_version_is_last":true,"title":["Robust information routing by dorsal subiculum neurons"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-31T02:38:21.365279+00:00"}