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直樹","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1000030253008","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000030253008"},{"nameIdentifier":"0000-0003-3249-7173","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0003-3249-7173"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Humboldt-Universitat zu Berlin","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Benson, Oliver","creatorNameLang":"en"},{"creatorName":"ベンソン, オリバー","creatorNameLang":"ja-Kana"},{"creatorName":"ベンソン, オリバー","creatorNameLang":"ja-Kana"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Keio University, Chapman University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Shikano, Yutaka","creatorNameLang":"en"},{"creatorName":"シカノ, ユタカ","creatorNameLang":"ja-Kana"},{"creatorName":"鹿野, 豊","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1000080634691","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000080634691"},{"nameIdentifier":"0000-0003-2107-7536","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0003-2107-7536"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Kage-Nakadai, Eriko","creatorNameLang":"en"},{"creatorName":"ナカダイ(カゲ), エリコ","creatorNameLang":"ja-Kana"},{"creatorName":"中台(鹿毛), 枝里子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1000040453790","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000040453790"},{"nameIdentifier":"0000-0001-5068-0460","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0001-5068-0460"}]}]},"item_1617186499011":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"クリエイティブ・コモンズ　表示 4.0 国際","subitem_rights_language":"ja","subitem_rights_resource":"https://creativecommons.org/licenses/by/4.0/"},{"subitem_rights":"Creative Commons Attribution 4.0 International","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by/4.0/"},{"subitem_rights":"© 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","subitem_rights_language":"en"}]},"item_1617186609386":{"attribute_name":"主題","attribute_value_mlt":[{"subitem_subject":"線虫","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"蛍光ナノダイヤモンド","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"量子温度計測","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"光検出磁気共鳴法","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Caenorhabditis elegans worm","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mobile nanodaiamonds","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"quantum nanothermometers","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"optically assessible electron spins","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究グループは、化学修飾した蛍光ナノダイヤモンドによる量子温度計測技術を開発し、成熟した動物(線虫C. elegans)個体の発熱を世界で初めて直接的に捉えることに成功しました。量子物理学・ナノ化学・生理学の垣根を超えた異分野融合によって成しえることのできた画期的な研究成果です。(参照[Link1])","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Real-time temperature monitoring inside living organisms provides a direct measure of their biological activities. However, it is challenging to reduce the size of biocompatible thermometers down to submicrometers, despite their potential applications for the thermal imaging of subtissue structures with single-cell resolution. Here, using quantum nanothermometers based on optically accessible electron spins in nanodiamonds, we demonstrate in vivo real-time temperature monitoring inside Caenorhabditis elegans worms. We developed a microscope system that integrates a quick-docking sample chamber, particle tracking, and an error correction filter for temperature monitoring of mobile nanodiamonds inside live adult worms with a precision of ±0.22℃. With this system, we determined temperature increases based on the worms' thermogenic responses during the chemical stimuli of mitochondrial uncouplers. Our technique demonstrates the submicrometer localization of temperature information in living animals and direct identification of their pharmacological thermogenesis, which may allow for quantification of their biological activities based on temperature.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"This work is supported in part by Osaka City University Strategic Research Grant 2017 and 2018 (M.F., E.K.-N., Y.S., and A.D.), Murata Science Foundation (M.F. and E.K.-N.), and JSPS-KAKENHI (20H00335, to M.F., Y.S., and E.K.-N; 16K13646 and 17H02741, to M.F.; 19K14636, to Y.S.; and 17H02738, to N.K.).","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Association for the Advancement of Science","subitem_publisher_language":"en"}]},"item_1617186783814":{"attribute_name":"識別子","attribute_value_mlt":[{"subitem_identifier_type":"DOI","subitem_identifier_uri":"https://doi.org/10.1126/sciadv.aba9636"}]},"item_1617186920753":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"2375-2548","subitem_source_identifier_type":"ISSN"}]},"item_1617187056579":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-09-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"37","bibliographicPageStart":"eaba9636","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"Science Advances","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1722232185104":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-09-23"}],"displaytype":"detail","filename":"23752548-6-37-eaba9636.pdf","filesize":[{"value":"2.7 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://ocu-omu.repo.nii.ac.jp/record/2020469/files/23752548-6-37-eaba9636.pdf"},"version_id":"e6de7633-0f09-451a-8bc0-381aad49c9d9"}]},"item_1722577087681":{"attribute_name":"記事種別等","attribute_value_mlt":[{"subitem_description":"RESEARCH ARTICLE","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_1725590125188":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_title":"Real-time nanodiamond thermometry probing in vivo thermogenic responses","item_type_id":"40002","owner":"7","path":["1721355153493"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-09-23"},"publish_date":"2020-09-23","publish_status":"0","recid":"2020469","relation_version_is_last":true,"title":["Real-time nanodiamond thermometry probing in vivo thermogenic responses"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-31T02:38:16.917776+00:00"}