{"created":"2024-10-31T02:36:09.528029+00:00","id":2020447,"links":{},"metadata":{"_buckets":{"deposit":"2d75f089-0f95-4eba-bbb2-42b0e0b388ea"},"_deposit":{"created_by":7,"id":"2020447","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2020447"},"status":"published"},"_oai":{"id":"oai:ocu-omu.repo.nii.ac.jp:02020447","sets":["1623632832836:1721355153493"]},"author_link":[],"item_1617186331708":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A gene-centric approach to biomarker discovery identifies transglutaminase 1 as an epidermal autoantigen","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Uppsala University, Karolinska Institutet","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Landegren, Nils","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Kurume University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Ishii, Norito","creatorNameLang":"en"},{"creatorName":"イシイ, ノリト","creatorNameLang":"ja-Kana"},{"creatorName":"石井, 文人","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Karolinska Institutet","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Aranda Guillen, Maribel","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Karolinska Institutet","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Gunnarsson, Hordur Ingi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Karolinska Institutet","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Sardh, Fabian","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Karolinska Institutet","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Hallgren, 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University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Ponten, Fredrik","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"University of Helsinki and Helsinki University Hospital, Karolinska Institutet, Karolinska University Hospital, Folkhälsan Institute of Genetics","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Makitie, Outi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Karolinska Institutet and Karolinska University Hospital","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Eidsmo, Liv","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"0000-0001-9237-8374","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0001-9237-8374"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Karolinska Institute, Karolinska University Hospital","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Norlen, 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University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Alimohammadi, Mohammad","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Karolinska Institutet, Karolinska University Hospital","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Eriksson, Danie","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Hashimoto, Takashi","creatorNameLang":"en"},{"creatorName":"ハシモト, タカシ","creatorNameLang":"ja-Kana"},{"creatorName":"橋本, 隆","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Karolinska Institutet, Karolinska University Hospital, University of Bergen","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Kampe, Olle","creatorNameLang":"en"},{"creatorName":"キム, アンドリュー ティー","creatorNameLang":"ja-Kana"}]}]},"item_1617186499011":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"クリエイティブ・コモンズ　表示 - 非営利 - 改変禁止 4.0 国際 ","subitem_rights_language":"ja","subitem_rights_resource":"https://creativecommons.org/licenses/by-nc-nd/4.0/ "},{"subitem_rights":"Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International ","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by-nc-nd/4.0/ "},{"subitem_rights":"Copyright © 2021 the Author(s). Published by PNAS.","subitem_rights_language":"en"}]},"item_1617186609386":{"attribute_name":"主題","attribute_value_mlt":[{"subitem_subject":"トランスグルタミナーゼ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"自己抗体探索システム","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"腫瘍随伴性天疱瘡","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"TGM1","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"共同研究グループは、自己抗原の候補タンパク質から各種自己免疫疾患の検体を用いて自己抗原を同定するという、これまでの研究方法(患者検体から自己抗原を探索)とは逆向きの自己抗原探索方法を開発しました。それにより、抗TGM1抗体が腫瘍随伴性天疱瘡の特異的診断マーカーとなることを示しました。自己抗原の同定は自己免疫性疾患の病態研究と診断に不可欠で、現在自己抗原の同定は、一般的に各疾患患者検体からそれぞれ自己抗原を同定するという手法が使用されています。TGM1は、これまでに遺伝性皮膚疾患との関連が示されてきましたが、後天性の自己免疫性皮膚疾患の自己抗原としては検討されていませんでした。そこで本研究グループは、TGM1を自己抗原の候補と考え、このタンパク質を標的として各種自己免疫性水疱症などの疾患の血清を探索しました。その結果、腫瘍随伴性天疱瘡で、55%の感度、100%の特異度で、抗TGM1抗体を検出することを発見しました。この結果により、腫瘍随伴性天疱瘡の確実な診断が容易になり、適切な治療につながることが期待されます。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Autoantigen discovery is a critical challenge for the understanding and diagnosis of autoimmune diseases. While autoantibody markers in current clinical use have been identified through studies focused on individual disorders, we postulated that a reverse approach starting with a putative autoantigen to explore multiple disorders might hold promise....","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1617186643794":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"National Academy of Sciences","subitem_publisher_language":"en"}]},"item_1617186783814":{"attribute_name":"識別子","attribute_value_mlt":[{"subitem_identifier_type":"DOI","subitem_identifier_uri":"https://doi.org/10.1073/pnas.2100687118"}]},"item_1617186920753":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"1091-6490","subitem_source_identifier_type":"ISSN"}]},"item_1617187056579":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-12-21","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"51","bibliographicPageStart":"e2100687118","bibliographicVolumeNumber":"118","bibliographic_titles":[{"bibliographic_title":"PNAS","bibliographic_titleLang":"en"},{"bibliographic_title":"Proceedings of the National Academy of Sciences of the United States of America","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"AA11726874","subitem_relation_type_select":"NCID"}}]},"item_1722232185104":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-12-27"}],"displaytype":"detail","filename":"10916490-118-51-e2100687118.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://ocu-omu.repo.nii.ac.jp/record/2020447/files/10916490-118-51-e2100687118.pdf"},"version_id":"747d7819-d27a-467f-a349-7280562e66ee"}]},"item_1722577087681":{"attribute_name":"記事種別等","attribute_value_mlt":[{"subitem_description":"Research Article","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_1725590125188":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_title":"A gene-centric approach to biomarker discovery identifies transglutaminase 1 as an epidermal autoantigen","item_type_id":"40002","owner":"7","path":["1721355153493"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-12-27"},"publish_date":"2021-12-27","publish_status":"0","recid":"2020447","relation_version_is_last":true,"title":["A gene-centric approach to biomarker discovery identifies transglutaminase 1 as an epidermal autoantigen"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-31T02:36:18.278437+00:00"}