{"created":"2024-10-31T02:35:54.764106+00:00","id":2020444,"links":{},"metadata":{"_buckets":{"deposit":"2f4462d7-44f2-4e0d-a399-037a200aa597"},"_deposit":{"created_by":7,"id":"2020444","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2020444"},"status":"published"},"_oai":{"id":"oai:ocu-omu.repo.nii.ac.jp:02020444","sets":["1623632832836:1721355153493"]},"author_link":[],"item_1617186331708":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Carob pod polyphenols suppress the differentiation of adipocytes through posttranscriptional regulation of C/EBPβ","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Fujita, Kasumi","creatorNameLang":"en"},{"creatorName":"フジタ, カスミ","creatorNameLang":"ja-Kana"},{"creatorName":"藤田, 華澄","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Aomori University of Health and Welfare","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Norikura, Toshio","creatorNameLang":"en"},{"creatorName":"ノリクラ, トシオ","creatorNameLang":"ja-Kana"},{"creatorName":"乗鞍, 敏夫","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1000040468111","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000040468111"},{"nameIdentifier":"0000-0002-8285-2965","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0002-8285-2965"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Matsui-Yuasa, Isao","creatorNameLang":"en"},{"creatorName":"ユアサ, イサオ","creatorNameLang":"ja-Kana"},{"creatorName":"湯浅, 勲","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1000050094488","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000050094488"},{"nameIdentifier":"read0020501","nameIdentifierScheme":"RESEARCHMAP","nameIdentifierURI":"https://researchmap.jp/read0020501"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"University of Shizuoka","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Kumazawa, Shigenori","creatorNameLang":"en"},{"creatorName":"クマザワ, シゲノリ","creatorNameLang":"ja-Kana"},{"creatorName":"熊澤, 茂則","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1000010295561","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000010295561"},{"nameIdentifier":"shige_kuma","nameIdentifierScheme":"RESEARCHMAP","nameIdentifierURI":"https://researchmap.jp/shige_kuma"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"University of Shizuoka","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Honda, Sari","creatorNameLang":"en"},{"creatorName":"ホンダ, サリ","creatorNameLang":"ja-Kana"},{"creatorName":"本田, 沙理","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1000020824890","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000020824890"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"TAISHO TECHNOS, Co., Ltd.","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Sonoda, Takumi","creatorNameLang":"en"},{"creatorName":"ソノダ, タクミ","creatorNameLang":"ja-Kana"},{"creatorName":"薗田, 拓実","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Kojima-Yuasa, Akiko ","creatorNameLang":"en"},{"creatorName":"コジマ, アキコ","creatorNameLang":"ja-Kana"},{"creatorName":"小島, 明子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1000090295709","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000090295709"},{"nameIdentifier":"0000-0001-8167-3693","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0001-8167-3693"}]}]},"item_1617186499011":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"クリエイティブ・コモンズ　表示 4.0 国際","subitem_rights_language":"ja","subitem_rights_resource":"https://creativecommons.org/licenses/by/4.0/"},{"subitem_rights":"Creative Commons Attribution 4.0 International","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by/4.0/"},{"subitem_rights":"© 2021 Fujita et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","subitem_rights_language":"en"}]},"item_1617186609386":{"attribute_name":"主題","attribute_value_mlt":[{"subitem_subject":"3T3-L1前駆脂肪細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"カロブパウダー抽出物","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"脂肪細胞への分化","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"anti-obesity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"3T3-L1 preadipocyte","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"posttranscriptional regulation of C","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"EBPβ","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"carob pod polyphenols (CPPs)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"differentiation of adipocytes","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究グループは、ココアパウダーやコーヒーパウダーの代替品としても用いられるカロブパウダー抽出物が抗肥満効果を有することを、細胞レベルおよび動物レベルで解明しました。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Obesity is a major risk factor for various chronic diseases such as diabetes, cardiovascular disease, and cancer; hence, there is an urgent need for an effective strategy to prevent this disorder. Currently, the anti-obesity effects of food ingredients are drawing attention. Therefore, we focused on carob, which has high antioxidant capacity and various physiological effects, and examined its anti-obesity effect. Carob is cultivated in the Mediterranean region, and its roasted powder is used as a substitute for cocoa powder. We investigated the effect of carob pod polyphenols (CPPs) on suppressing increases in adipose tissue weight and adipocyte hypertrophy in high fat diet-induced obesity model mice, and the mechanism by which CPPs inhibit the differentiation of 3T3-L1 preadipocytes into adipocytes in vitro. In an in vivo experimental system, we revealed that CPPs significantly suppressed the increase in adipose tissue weight and adipocyte hypertrophy. Moreover, in an in vitro experimental system, CPPs acted at the early stage of differentiation of 3T3-L1 preadipocytes and suppressed cell proliferation because of differentiation induction. They also suppressed the expression of transcription factors involved in adipocyte differentiation, thereby reducing triacylglycerol synthesis ability and triglycerol (TG) accumulation. Notably, CPPs regulated CCAAT/enhancer binding protein (C/EBP)β, which is expressed at the early stage of differentiation, at the posttranscriptional level. These results demonstrate that CPPs suppress the differentiation of adipocytes through the posttranscriptional regulation of C/EBPβ and may serve as an effective anti-obesity compound.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"This work was supported by JSPS KAKENHI (Grant Number JP15K00832). KAKENHI aims to significantly develop all \"academic research\" from basic to applied (research based on the free thinking of researchers). TAISHO TECHNOS, Co., Ltd. provided the Carob pod polyphenols, a part of the grant, and support in the form of salary for T.S., but did not have any additional role in the study design data collection and analysis decision to publish, or preparation of the manuscript. The specific role of T.S. is articulated in the “Author Contributions” section.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science","subitem_publisher_language":"en"}]},"item_1617186783814":{"attribute_name":"識別子","attribute_value_mlt":[{"subitem_identifier_type":"DOI","subitem_identifier_uri":"https://doi.org/10.1371/journal.pone.0248073"}]},"item_1617186920753":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"1932-6203","subitem_source_identifier_type":"ISSN"}]},"item_1617187056579":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-03-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageStart":"e0248073","bibliographicVolumeNumber":"16","bibliographic_titles":[{"bibliographic_title":"PLOS ONE","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1722232185104":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-03-17"}],"displaytype":"detail","filename":"19326203-16-3-e0248073.pdf","filesize":[{"value":"5.7 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://ocu-omu.repo.nii.ac.jp/record/2020444/files/19326203-16-3-e0248073.pdf"},"version_id":"2ee4159c-ee70-444f-9dfe-9031a243d2f2"}]},"item_1722577087681":{"attribute_name":"記事種別等","attribute_value_mlt":[{"subitem_description":"Research Article","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_1725590125188":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_title":"Carob pod polyphenols suppress the differentiation of adipocytes through posttranscriptional regulation of C/EBPβ","item_type_id":"40002","owner":"7","path":["1721355153493"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-03-17"},"publish_date":"2021-03-17","publish_status":"0","recid":"2020444","relation_version_is_last":true,"title":["Carob pod polyphenols suppress the differentiation of adipocytes through posttranscriptional regulation of C/EBPβ"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-31T02:36:02.955893+00:00"}