{"created":"2024-10-31T01:54:33.470474+00:00","id":2020183,"links":{},"metadata":{"_buckets":{"deposit":"d56b64eb-d81c-43bc-bdad-d53d3b0fbf7d"},"_deposit":{"created_by":7,"id":"2020183","owner":"7","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2020183"},"status":"published"},"_oai":{"id":"oai:ocu-omu.repo.nii.ac.jp:02020183","sets":["1623632832836:1721355153493"]},"author_link":[],"control_number":"2020183","item_1617186331708":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The Fermented Soy Product ImmuBalanceTM Suppresses Airway Inflammation in a Murine Model of Asthma","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Kadotani, Hideaki","creatorNameLang":"en"},{"creatorName":"カドタニ, 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佳奈子","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Yamada, Kazuhiro","creatorNameLang":"en"},{"creatorName":"ヤマダ, カズヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"山田, 一宏","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Ijiri, Naoki","creatorNameLang":"en"},{"creatorName":"イジリ, ナオキ","creatorNameLang":"ja-Kana"},{"creatorName":"井尻, 尚樹","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1000010567788","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000010567788"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Watanabe, Tetsuya","creatorNameLang":"en"},{"creatorName":"ワタナベ, テツヤ","creatorNameLang":"ja-Kana"},{"creatorName":"渡辺, 徹也","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1000040735122","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000040735122"},{"nameIdentifier":"7000024347","nameIdentifierScheme":"RESEARCHMAP","nameIdentifierURI":"https://researchmap.jp/7000024347"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Kawaguchi, Tomoya","creatorNameLang":"en"},{"creatorName":"カワグチ, トモヤ","creatorNameLang":"ja-Kana"},{"creatorName":"川口, 知哉","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1000070254422","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000070254422"},{"nameIdentifier":"0000-0002-1338-9970","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0002-1338-9970"}]}]},"item_1617186499011":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"クリエイティブ・コモンズ　表示 4.0 国際","subitem_rights_language":"ja","subitem_rights_resource":"https://creativecommons.org/licenses/by/4.0/"},{"subitem_rights":"Creative Commons Attribution 4.0 International","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by/4.0/"},{"subitem_rights":"© 2021 by the authors. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/.","subitem_rights_language":"en"}]},"item_1617186609386":{"attribute_name":"主題","attribute_value_mlt":[{"subitem_subject":"大豆発酵製品","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"喘息","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"好酸球性炎症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Th2サイトカイン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"イムバランス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"fermented soy product","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"asthma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"eosinophilic inflammation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Th2 cytokines","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究グループは、大豆発酵製品であるイムバランスが喘息による気道炎症を抑制する効果があることを動物モデルで明らかにしました。気管支喘息は慢性的な気道炎症により喘鳴や呼吸困難などの症状が現れますが、根本的な治療方法がなく、新たな予防・治療法の確立が望まれています。大豆の摂取とアレルギー疾患との関連は過去にも疫学的に報告されており、大豆の成分に何らかの抗アレルギー作用がある可能性が示唆されています。そこで、本研究グループは、喘息モデルマウスにイムバランスを添加した飼料を与えて気道炎症に及ぼす影響を調査しました。その結果、イムバランス投与群では、BALF(気管支肺胞洗浄液)中の好酸球数が有意に減少し、気管支周囲の炎症や粘液産生が抑制されていることを発見しました。また、好酸球性炎症を誘導するBALF中のTh2サイトカインや血清IgEの発現も有意に抑制されていました。この発見により、今後イムバランスが気管支喘息における治療方法の新規候補として期待されます。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"The fermented soy product ImmuBalance contains many active ingredients and its beneficial effects on some allergic diseases have been reported. We hypothesized that ImmuBalance could have potential effects on airway inflammation in a murine model of asthma. Mice sensitized and challenged with ovalbumin developed airway inflammation. Bronchoalveolar lavage fluid was assessed for inflammatory cell counts and levels of cytokines. Lung tissues were examined for cell infiltration and mucus hypersecretion. Oral administration of ImmuBalance significantly inhibited ovalbumin-induced eosinophilic inflammation and decreased Th2 cytokine levels in bronchoalveolar lavage fluid (p < 0.05). In addition, lung histological analysis showed that ImmuBalance inhibited inflammatory cell infiltration and airway mucus production. Our findings suggest that supplementation with ImmuBalance may provide a novel strategy for the prevention or treatment of allergic airway inflammation.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"This work was partly supported by a Grant-in-Aid for Scientific Research, grant number 19K08660.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_1617186783814":{"attribute_name":"識別子","attribute_value_mlt":[{"subitem_identifier_type":"DOI","subitem_identifier_uri":"https://doi.org/10.3390/nu13103380"}]},"item_1617186920753":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"2072-6643","subitem_source_identifier_type":"ISSN"}]},"item_1617187056579":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-09-26","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageStart":"3380","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"Nutrients","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"item_1617258105262","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1722232185104":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-10-12"}],"displaytype":"detail","filename":"20726643-13-10-3380.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://ocu-omu.repo.nii.ac.jp/record/2020183/files/20726643-13-10-3380.pdf"},"version_id":"2079e26a-c259-4ed7-9aab-ba8b06bcce07"}]},"item_1722577087681":{"attribute_name":"記事種別等","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_1725590125188":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_title":"The Fermented Soy Product ImmuBalanceTM Suppresses Airway Inflammation in a Murine Model of Asthma","item_type_id":"40002","owner":"7","path":["1721355153493"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-10-12"},"publish_date":"2021-10-12","publish_status":"0","recid":"2020183","relation_version_is_last":true,"title":["The Fermented Soy Product ImmuBalanceTM Suppresses Airway Inflammation in a Murine Model of Asthma"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-03-14T02:30:52.040823+00:00"}