{"created":"2024-10-31T01:47:54.780059+00:00","id":2020112,"links":{},"metadata":{"_buckets":{"deposit":"360f0d3a-e0f6-4a1b-b84c-315abf6ea280"},"_deposit":{"created_by":7,"id":"2020112","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2020112"},"status":"published"},"_oai":{"id":"oai:ocu-omu.repo.nii.ac.jp:02020112","sets":["1623632832836:1721355153493"]},"author_link":[],"item_1617186331708":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"De novo inter-regional coactivations of preconfigured local ensembles support memory","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City Unviersity","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Miyawaki, Hiroyuki","creatorNameLang":"en"},{"creatorName":"ミヤワキ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"宮脇, 寛行","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1000040785979","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000040785979"},{"nameIdentifier":"0000-0003-1556-1348","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0003-1556-1348"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City Unviersity","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Mizuseki, Kenji","creatorNameLang":"en"},{"creatorName":"ミズセキ, ケンジ","creatorNameLang":"ja-Kana"},{"creatorName":"水関, 健司","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1000080344448","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000080344448"},{"nameIdentifier":"0000-0002-1456-2149","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0002-1456-2149"}]}]},"item_1617186499011":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"クリエイティブ・コモンズ　表示 4.0 国際","subitem_rights_language":"ja","subitem_rights_resource":"https://creativecommons.org/licenses/by/4.0/"},{"subitem_rights":"Creative Commons Attribution 4.0 International","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by/4.0/"},{"subitem_rights":"© 2022 the Author(s).","subitem_rights_language":"en"}]},"item_1617186609386":{"attribute_name":"主題","attribute_value_mlt":[{"subitem_subject":"記憶","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"脳領域間ネットワーク","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"脳領域横断的同期活動","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"バースト活動","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究グループは、様々な脳領域に存在するアンサンブル(同時に活動し特定の記憶情報を表現する神経細胞集団)が、記憶の獲得後に同期して活動するようになることを世界で初めて明らかにしました。また本研究では、脳領域横断的な同期活動が100ミリ秒程度の一過的な脳波上のバースト活動の際に特に強く生じることも明らかにしました。これらは、新たな経験の情報が既に存在している活動パターンに紐付けられることで保持され、それらのパターン同士が一過的なバースト活動を介して脳領域横断的に繋がり合うことで記憶が形成されることを示した世界初の成果です。脳は経験したことを素早く記憶する柔軟性と、記憶したことを長期間保持する安定性の2つの相反する性質を両立させています。本研究の結果は、「記憶の獲得前から存在する局所ネットワーク」と「経験依存的に生じる脳領域横断的なネットワーク」という異なるダイナミクスをもつネットワークを組み合わせることで、脳が柔軟性と安定性を両立させている可能性を示唆しています。これはヒトを含む動物の記憶メカニズムに迫る成果であり、認知症や心的外傷後ストレス障害などの記憶機能関連障害の病態解明に繋がることが期待されます。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Neuronal ensembles in the amygdala, ventral hippocampus, and prefrontal cortex are involved in fear memory; however, how inter-regional ensemble interactions support memory remains elusive. Using multi-regional large-scale electrophysiology in the aforementioned structures of fear-conditioned rats, we found that the local ensembles activated during fear memory acquisition are inter-regionally coactivated during the subsequent sleep period, which relied on brief bouts of fast network oscillations. During memory retrieval, the coactivations reappeared, together with fast oscillations. Coactivation-participating-ensembles were configured prior to memory acquisition in the amygdala and prefrontal cortex but developed through experience in the hippocampus. Our findings suggest that elements of a given memory are instantly encoded within various brain regions in a preconfigured manner, whereas hippocampal ensembles and the network for inter-regional integration of the distributed information develop in an experience-dependent manner to form a new memory, which is consistent with the hippocampal memory index hypothesis.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"This work was supported by JSPS KAKENHI(20K06860, 20H05477, and 19H04986 to H.M.; 21H00209, 20H03356, 19H05225, 16H04656, and 16H01279 to K.M.).","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature","subitem_publisher_language":"en"}]},"item_1617186783814":{"attribute_name":"識別子","attribute_value_mlt":[{"subitem_identifier_type":"DOI","subitem_identifier_uri":"https://doi.org/10.1038/s41467-022-28929-x"}]},"item_1617186920753":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"2041-1723","subitem_source_identifier_type":"ISSN"}]},"item_1617187056579":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-03-11","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"1272","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"Nature Communications","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"AA12645905","subitem_relation_type_select":"NCID"}}]},"item_1722232185104":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-23"}],"displaytype":"detail","filename":"20411723-13-1272.pdf","filesize":[{"value":"4.0 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://ocu-omu.repo.nii.ac.jp/record/2020112/files/20411723-13-1272.pdf"},"version_id":"ecf539e2-7648-4816-9557-4bb13bcb1025"}]},"item_1722577087681":{"attribute_name":"記事種別等","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_1725590125188":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_title":"De novo inter-regional coactivations of preconfigured local ensembles support memory","item_type_id":"40002","owner":"7","path":["1721355153493"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-03-23"},"publish_date":"2022-03-23","publish_status":"0","recid":"2020112","relation_version_is_last":true,"title":["De novo inter-regional coactivations of preconfigured local ensembles support memory"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-31T01:48:02.501446+00:00"}