{"created":"2024-10-31T01:45:58.860111+00:00","id":2020089,"links":{},"metadata":{"_buckets":{"deposit":"4e8c2c99-1b17-4dec-9a7d-3d1bcf953c65"},"_deposit":{"created_by":7,"id":"2020089","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2020089"},"status":"published"},"_oai":{"id":"oai:ocu-omu.repo.nii.ac.jp:02020089","sets":["1623632832836:1721355153493"]},"author_link":[],"item_1617186331708":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The Prognostic Impact of Tumor Differentiation on Recurrence and Survival after Resection of Hepatocellular Carcinoma Is Dependent on Tumor Size","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Shinkawa, Hiroji","creatorNameLang":"en"},{"creatorName":"シンカワ, ヒロジ","creatorNameLang":"ja-Kana"},{"creatorName":"新川, 寛二","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1000000554932","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000000554932"},{"nameIdentifier":"0000-0002-0164-2414","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0002-0164-2414"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Tanaka, Shogo","creatorNameLang":"en"},{"creatorName":"タナカ, ショウゴ","creatorNameLang":"ja-Kana"},{"creatorName":"田中, 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University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Takemura, Shigekazu","creatorNameLang":"en"},{"creatorName":"タケムラ, シゲカズ","creatorNameLang":"ja-Kana"},{"creatorName":"竹村, 茂一","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1000000322363","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000000322363"},{"nameIdentifier":"0000-0002-5221-7258","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0002-5221-7258"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Amano, Ryosuke","creatorNameLang":"en"},{"creatorName":"アマノ, リョウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"天野, 良亮","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"read0138922","nameIdentifierScheme":"RESEARCHMAP","nameIdentifierURI":"https://researchmap.jp/read0138922"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Kimura, Kenjiro","creatorNameLang":"en"},{"creatorName":"キムラ, ケンジロウ","creatorNameLang":"ja-Kana"},{"creatorName":"木村, 健二郎","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1000060597285","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000060597285"},{"nameIdentifier":"read0154407","nameIdentifierScheme":"RESEARCHMAP","nameIdentifierURI":"https://researchmap.jp/read0154407"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Kinoshita, Masahiko","creatorNameLang":"en"},{"creatorName":"キノシタ, マサヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"木下, 正彦","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Kubo, Shoji","creatorNameLang":"en"},{"creatorName":"クボ, ショウジ","creatorNameLang":"ja-Kana"},{"creatorName":"久保, 正二","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1000080221224","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000080221224"},{"nameIdentifier":"7000022826","nameIdentifierScheme":"RESEARCHMAP","nameIdentifierURI":"https://researchmap.jp/7000022826"}]}]},"item_1617186499011":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"クリエイティブ・コモンズ　表示 - 非営利 4.0 国際","subitem_rights_language":"ja","subitem_rights_resource":"https://creativecommons.org/licenses/by-nc/4.0/ "},{"subitem_rights":"Creative Commons Attribution-NonCommercial 4.0 International","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by-nc/4.0/ "},{"subitem_rights":"© 2021 The Author(s). Published by S. Karger AG, Basel.","subitem_rights_language":"en"}]},"item_1617186609386":{"attribute_name":"主題","attribute_value_mlt":[{"subitem_subject":"腫瘍分化度","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"肝細胞癌","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"腫瘍サイズ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"予後","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Tumor differentiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hepatocellular carcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Tumor size","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Prognosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究グループは、肝細胞癌の腫瘍分化度による予後不良リスクは腫瘍サイズとともに増大することを明らかにしました。近年国内でも増加している生活習慣病などが原因となって発症する肝細胞癌ですが、肝細胞癌における腫瘍分化度と予後との関連性は一定の見解が得られておらず、欧州肝臓学会のガイドラインでも「結論に至っていない」と示されています。今回1,107例の肝細胞癌肝切除症例を対象に検討したところ、低分化型は術後予後不良因子であり、腫瘍サイズ5cmまでは予後不良リスクが急激に上昇することが分かりました。腫瘍サイズを<2cm、2-5cm、≥ 5cmに群別して検討したところ、腫瘍サイズ<2cmでは低分化型は予後への影響は認められませんでしたが、腫瘍サイズ2-5cm、≥ 5 cmでは低分化型は1.33倍、1.58倍に予後不良リスクが増大していました。また、腫瘍サイズ2-5cm、≥ 5cmでは低分化型は術後早期再発(2年以内)のリスクが1.34倍、1.57倍に増大していました。さらに、腫瘍サイズ≥ 5 cmでは低分化型は術後早期遠隔転移のリスクが2.33倍に増大していました。本研究により、低分化型肝細胞癌は腫瘍サイズ2cm以上で予後不良リスクとなり、特に5cm以上では術後早期遠隔転移のリスクが増大することが分かりました。本研究の成果は、肝細胞癌患者への新たな戦略としての応用や術後の肝外再発の早期発見につながることが期待されます。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Introduction: The present study aimed to evaluate the effect of poor differentiation and tumor size on survival outcome after hepatic resection of hepatocellular carcinoma (HCC). / Methods: A total of 1,107 patients who underwent initial and curative hepatic resection for HCC without macroscopic vascular invasion participated in the study. Using the multivariable Cox proportional hazards regression model, we evaluated changes in hazard ratios (HRs) for the association between tumor differentiation and survival based on tumor size....","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1617186643794":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"KARGER","subitem_publisher_language":"en"}]},"item_1617186783814":{"attribute_name":"識別子","attribute_value_mlt":[{"subitem_identifier_type":"DOI","subitem_identifier_uri":"https://doi.org/10.1159/000517992"}]},"item_1617186920753":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"1664-5553","subitem_source_identifier_type":"ISSN"}]},"item_1617187056579":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"472","bibliographicPageStart":"461","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"Liver Cancer","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"AA12610897","subitem_relation_type_select":"NCID"}}]},"item_1722232185104":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-10-05"}],"displaytype":"detail","filename":"16645553-10-5-461.pdf","filesize":[{"value":"773.6 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://ocu-omu.repo.nii.ac.jp/record/2020089/files/16645553-10-5-461.pdf"},"version_id":"45bd7398-acef-4444-9f8e-3359172ee269"}]},"item_1722577087681":{"attribute_name":"記事種別等","attribute_value_mlt":[{"subitem_description":"Research Article","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_1725590125188":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_title":"The Prognostic Impact of Tumor Differentiation on Recurrence and Survival after Resection of Hepatocellular Carcinoma Is Dependent on Tumor Size","item_type_id":"40002","owner":"7","path":["1721355153493"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-10-05"},"publish_date":"2021-10-05","publish_status":"0","recid":"2020089","relation_version_is_last":true,"title":["The Prognostic Impact of Tumor Differentiation on Recurrence and Survival after Resection of Hepatocellular Carcinoma Is Dependent on Tumor Size"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-31T01:46:08.006094+00:00"}