{"created":"2024-10-31T01:33:16.790238+00:00","id":2019983,"links":{},"metadata":{"_buckets":{"deposit":"a79953e1-653b-41f3-b8bd-1901d838f26f"},"_deposit":{"created_by":7,"id":"2019983","owner":"7","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2019983"},"status":"published"},"_oai":{"id":"oai:ocu-omu.repo.nii.ac.jp:02019983","sets":["1623632832836:1721355153493"]},"author_link":[],"control_number":"2019983","item_1617186331708":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Ninjin'yoeito Ameliorates Skeletal Muscle Complications in COPD Model Mice by Upregulating Peroxisome Proliferator-Activated Receptor γ Coactivator-1α Expression","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Miyamoto, Atsushi","creatorNameLang":"en"},{"creatorName":"ミヤモト, アツシ","creatorNameLang":"ja-Kana"},{"creatorName":"宮本, 敦史","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1000000362731","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000000362731"},{"nameIdentifier":"0000-0001-6847-9925","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0001-6847-9925"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Asai, Kazuhisa","creatorNameLang":"en"},{"creatorName":"アサイ, カズヒサ","creatorNameLang":"ja-Kana"},{"creatorName":"浅井, 一久","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1000010382053","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000010382053"},{"nameIdentifier":"0000-0001-8400-863X","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0001-8400-863X"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Kadotani, Hideaki","creatorNameLang":"en"},{"creatorName":"カドタニ, ヒデアキ","creatorNameLang":"ja-Kana"},{"creatorName":"門谷, 英昭","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"0000-0002-2532-9262","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0002-2532-9262"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Maruyama, Naomi","creatorNameLang":"en"},{"creatorName":"マルヤマ, ナオミ","creatorNameLang":"ja-Kana"},{"creatorName":"丸山, 直美","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Kubo, Hiroaki","creatorNameLang":"en"},{"creatorName":"クボ, ヒロアキ","creatorNameLang":"ja-Kana"},{"creatorName":"久保, 寛明","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"0000-0002-5973-9745","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0002-5973-9745"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Okamoto, Atsuko","creatorNameLang":"en"},{"creatorName":"オカモト, アツコ","creatorNameLang":"ja-Kana"},{"creatorName":"岡本, 敦子","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Sato, Kanako","creatorNameLang":"en"},{"creatorName":"サトウ, カナコ","creatorNameLang":"ja-Kana"},{"creatorName":"佐藤, 佳奈子","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Yamada, Kazuhiro","creatorNameLang":"en"},{"creatorName":"ヤマダ, カズヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"山田, 一宏","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Ijiri, Naoki","creatorNameLang":"en"},{"creatorName":"イジリ, ナオキ","creatorNameLang":"ja-Kana"},{"creatorName":"井尻, 尚樹","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1000010567788","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000010567788"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Watanabe, Tetsuya","creatorNameLang":"en"},{"creatorName":"ワタナベ, テツヤ","creatorNameLang":"ja-Kana"},{"creatorName":"渡辺, 徹也","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1000040735122","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000040735122"},{"nameIdentifier":"7000024347","nameIdentifierScheme":"RESEARCHMAP","nameIdentifierURI":"https://researchmap.jp/7000024347"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Kawaguchi, Tomoya","creatorNameLang":"en"},{"creatorName":"カワグチ, トモヤ","creatorNameLang":"ja-Kana"},{"creatorName":"川口, 知哉","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1000070254422","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000070254422"},{"nameIdentifier":"0000-0002-1338-9970","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0002-1338-9970"}]}]},"item_1617186499011":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.","subitem_rights_language":"en"}]},"item_1617186609386":{"attribute_name":"主題","attribute_value_mlt":[{"subitem_subject":"慢性閉塞性肺疾患","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"サルコペニア","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ペルオキシソーム増殖因子活性化レセプターγ共役因子1α","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"人参養栄湯","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"筋肉減少症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"chronic obstructive pulmonary disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"sarcopenia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"peroxisome proliferator-activated receptor γ coactivator-1α","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ninjin'yoeito","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"muscle dysfunction","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究グループは、病後や術後の食欲不振に処方される漢方薬「人参養栄湯」がCOPD(慢性閉塞性肺疾患)の骨格筋合併症に効果があることを明らかにしました。加齢や疾患により筋力が衰え、疲れやすくなり家に閉じこもりがちになるなど、健常から要介護へ移行する中間の段階である衰え全般を「フレイル」と呼び、健康寿命増進のための課題として注目されています。COPDは主にタバコ煙を吸入することにより肺胞が破壊されたり気管支が傷害されたりして生じる肺疾患であり、咳や痰、息切れの他にしばしばフレイルの中核である筋萎縮や筋力低下といった「サルコペニア(筋肉減少症)」を合併します。フレイル・サルコペニアはCOPDの予後を悪化させる因子として知られており、COPDによる死亡者数増加の一端を担っていると考えられます。そのため、COPDの骨格筋合併症に対する治療は喫緊の課題ですが、運動療法以外に単独の効果が確立されたものがないのが現状です。本研究では、人参養栄湯投与により骨格筋組織においてPGC-1α発現が亢進し、COPDモデルマウスの骨格筋合併症が改善されることが示されました。COPD患者においても人参養栄湯を摂取することでサルコペニア・フレイルの悪循環を断ち切ることができる可能性が示され、今まで克服が困難であったCOPDの骨格筋合併症の新たな治療戦略として注目されます。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Purpose: Sarcopenia, the loss of skeletal muscle mass and strength, is a common systemic consequence of chronic obstructive pulmonary disease (COPD) and is correlated with higher mortality. Ninjin’yoeito (NYT) is a Japanese herbal medicine used to treat athrepsia and anorexia and is reported to ameliorate weight loss and muscular dysfunction. Recent studies have shown that its crude components upregulate the peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α)-related pathway, which is involved in skeletal muscle functions. Here, we examined whether NYT improves skeletal muscle complications by upregulating PGC-1α in COPD model mice. / Materials and Methods: Mice were divided into four groups: control, NYT, smoking, and smoking + NYT. The smoking and smoking + NYT groups were exposed to cigarette smoke for 60 min once daily....","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"This work was partially supported by JSPS KAKENHI (Grant-in-Aid for Scientific Research [C]) Grant Number 19K08660 to K. A.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Dove Medical Press","subitem_publisher_language":"en"}]},"item_1617186783814":{"attribute_name":"識別子","attribute_value_mlt":[{"subitem_identifier_type":"DOI","subitem_identifier_uri":"https://doi.org/10.2147/COPD.S280401"}]},"item_1617186920753":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"1178-2005","subitem_source_identifier_type":"ISSN"}]},"item_1617187056579":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-11-27","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"15","bibliographicPageEnd":"3077","bibliographicPageStart":"3063","bibliographicVolumeNumber":"2020","bibliographic_titles":[{"bibliographic_title":"International Journal of Chronic Obstructive Pulmonary Disease","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"item_1617258105262","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1722232185104":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-11"}],"displaytype":"detail","filename":"11782005-2020-15-3063.pdf","filesize":[{"value":"29.5 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://ocu-omu.repo.nii.ac.jp/record/2019983/files/11782005-2020-15-3063.pdf"},"version_id":"ce6ff84d-c94e-46ee-a15a-2902707c920a"}]},"item_1722577087681":{"attribute_name":"記事種別等","attribute_value_mlt":[{"subitem_description":"ORIGINAL RESEARCH","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_1725590125188":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_title":"Ninjin'yoeito Ameliorates Skeletal Muscle Complications in COPD Model Mice by Upregulating Peroxisome Proliferator-Activated Receptor γ Coactivator-1α Expression","item_type_id":"40002","owner":"7","path":["1721355153493"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-12-11"},"publish_date":"2020-12-11","publish_status":"0","recid":"2019983","relation_version_is_last":true,"title":["Ninjin'yoeito Ameliorates Skeletal Muscle Complications in COPD Model Mice by Upregulating Peroxisome Proliferator-Activated Receptor γ Coactivator-1α Expression"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-03-14T02:04:03.302155+00:00"}