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of the Liver. Published by Elsevier B.V.","subitem_rights_language":"en"}]},"item_1617186609386":{"attribute_name":"主題","attribute_value_mlt":[{"subitem_subject":"非アルコール性脂肪肝炎","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"肝線維化","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"サイトグロビン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"トランスフォーミング増殖因子-β1","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"酸化ストレス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"星細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"NAFLD","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NASH","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Liver fibrosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cytoglobin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"TGF-β1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Oxidative stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hepatic stellate cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究グループは、肝障害を改善する可能性が期待されているサイトグロビンが酸化ストレスで生じるDNA損傷から細胞を保護する役割があることを明らかにしました。ウイルスや飲酒、肥満が原因で生じる肝線維化は難治性疾患であり、治療をしなかった場合は肝硬変へと進展し、その2~8％は肝がんを発症します。先行研究にてサイトグロビンに肝障害を改善する可能性があることは報告されていますが、肝線維化との関連については明らかにされていませんでした。そこで本研究では、脂肪肝患者の肝線維化とサイトグロビンの発現変動を調べたところ、肝線維化の進展に伴い、線維化促進因子であるtransforming growth factor(TGF)-βの過剰産生とサイトグロビンの発現量の減少が観察されました。また、サイトグロビン発現の低い患者では、酸化的DNA損傷が増加することを発見しました。この結果は、サイトグロビンが肝線維化の早期診断指標になる可能性を示唆しており、初期段階から治療に取り組むことが可能になるだけでなく、今後サイトグロビンの発現誘導剤を用いた新たな治療法の開発につながる大きな成果といえます。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Cytoglobin (CYGB) is a respiratory protein that acts as a scavenger of reactive oxygen species and protects cells from oxidative DNA damage. Herein, we show that the cytokine TGF-β1 downregulates human CYGB expression. This leads to oxidative DNA damage in activated hepatic stellate cells. Our findings provide new insights into the relationship between CYGB expression and the pathophysiology of fibrosis in patients with non-alcoholic steatohepatitis.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"This work was supported by a Grant-in-Aid for Scientific Research (C) from Japan Society for the Promotion of Science (JSPS) KAKENHI JP15K08314 (to MSM) and by a Grant-in-Aid for Scientific Research (B) from JSPS KAKENHI JP16H05290 and a Grant for Research Program on Hepatitis from the Japan Agency for Medical Research and Development (AMED – JP18fk0210004 and JP19fk0210050) (to NK).","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_1617186783814":{"attribute_name":"識別子","attribute_value_mlt":[{"subitem_identifier_type":"DOI","subitem_identifier_uri":"https://doi.org/10.1016/j.jhep.2020.03.051"}]},"item_1617186920753":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"0168-8278","subitem_source_identifier_type":"ISSN"}]},"item_1617187056579":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"895","bibliographicPageStart":"882","bibliographicVolumeNumber":"73","bibliographic_titles":[{"bibliographic_title":"Journal of Hepatology","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"item_1617258105262","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"AA11532517","subitem_relation_type_select":"NCID"}}]},"item_1722232185104":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-09"}],"displaytype":"detail","filename":"01688278-73-4-882.pdf","filesize":[{"value":"4.7 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://ocu-omu.repo.nii.ac.jp/record/2019982/files/01688278-73-4-882.pdf"},"version_id":"e4f764d2-aab9-4a45-b3f6-747a8ef53482"}]},"item_1722577087681":{"attribute_name":"記事種別等","attribute_value_mlt":[{"subitem_description":"Research article","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_1725590125188":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_title":"TGF-β1-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis","item_type_id":"40002","owner":"7","path":["1721355153493"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-11-09"},"publish_date":"2020-11-09","publish_status":"0","recid":"2019982","relation_version_is_last":true,"title":["TGF-β1-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-03-14T02:25:21.447098+00:00"}