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The article has been published in final form at https://doi.org/10.1016/j.ijantimicag.2019.05.018","subitem_rights_language":"en"}]},"item_1617186609386":{"attribute_name":"主題","attribute_value_mlt":[{"subitem_subject":"高病原性肺炎桿菌","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"粘液活性","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"リファンピシン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"hypervirulent klebsiella pneumoniae","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hypermucoviscous","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"capsular polysaccharide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"rifampicin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"anti-mucoviscous","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"antivirulence agent","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"リファンピシンが粘液活性を減少させ、高病原性肺炎桿菌の病原性を低下させることを見出した。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"A recent increase in the incidence of hypervirulent Klebsiella pneumoniae (hvKP) infections, especially those caused by a sublineage of the clonal group CG23 (CG23-I), is raising serious health concerns worldwide. The high virulence of hvKP is, at least in part, attributed to the overproduction of capsular polysaccharide (CPS), which is triggered by a positive regulator of capsular polysaccharide synthesis (cps) genes, named RmpA. Although extensive research has been conducted on the mechanisms ofhvKP virulence, no study has focused on the development of anti-virulence therapeutics....","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"This study was supported by the Research Program on Emerging and Re-emerging Infectious Diseases from the Japan Agency Development, AMED (Grant number JP 17fk0108208 and 18fk0108052h0002) and JSPS KAKENHI (Grant number 16K09939).","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_1617186783814":{"attribute_name":"識別子","attribute_value_mlt":[{"subitem_identifier_type":"DOI","subitem_identifier_uri":"https://doi.org/10.1016/j.ijantimicag.2019.05.018"}]},"item_1617186920753":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"0924-8579","subitem_source_identifier_type":"ISSN"}]},"item_1617187056579":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"175","bibliographicPageStart":"167","bibliographicVolumeNumber":"54","bibliographic_titles":[{"bibliographic_title":"International Journal of Antimicrobial Agents","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_b1a7d7d4d402bcce","subitem_version_type":"AO"}]},"item_1617353299429":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.ijantimicag.2019.05.018","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"AA11530817","subitem_relation_type_select":"NCID"}}]},"item_1722232185104":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-09-02"}],"displaytype":"detail","filename":"09248579-54-2-167.pdf","filesize":[{"value":"920.0 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://ocu-omu.repo.nii.ac.jp/record/2019901/files/09248579-54-2-167.pdf"},"version_id":"dcccc20f-3609-4d59-9bc0-89063a886eb8"}]},"item_1722577087681":{"attribute_name":"記事種別等","attribute_value_mlt":[{"subitem_description":"Research Article","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_1725590125188":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_title":"Discovery of anti-mucoviscous activity of rifampicin and its potential as a candidate anti-virulence agent against hypervirulent Klebsiella pneumoniae","item_type_id":"40002","owner":"7","path":["1721355153493"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-09-02"},"publish_date":"2020-09-02","publish_status":"0","recid":"2019901","relation_version_is_last":true,"title":["Discovery of anti-mucoviscous activity of rifampicin and its potential as a candidate anti-virulence agent against hypervirulent Klebsiella pneumoniae"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-31T01:25:41.107416+00:00"}