{"created":"2024-10-31T01:20:35.699156+00:00","id":2019872,"links":{},"metadata":{"_buckets":{"deposit":"446a0298-8c03-45d0-bdfe-a2ee0df6fbe3"},"_deposit":{"created_by":7,"id":"2019872","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2019872"},"status":"published"},"_oai":{"id":"oai:ocu-omu.repo.nii.ac.jp:02019872","sets":["1623632832836:1721355153493"]},"author_link":[],"item_1617186331708":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Sesaminol prevents Parkinson's disease by activating the Nrf2-ARE signaling pathway","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Kaji, Haruka","creatorNameLang":"en"},{"creatorName":"カジ, ハルカ","creatorNameLang":"ja-Kana"},{"creatorName":"鍛冶, 春花","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Matsui-Yuasa, Isao","creatorNameLang":"en"},{"creatorName":"ユアサ(マツイ), イサオ","creatorNameLang":"ja-Kana"},{"creatorName":"湯浅(松井), 勲","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1000050094488","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000050094488"},{"nameIdentifier":"read0020501","nameIdentifierScheme":"RESEARCHMAP","nameIdentifierURI":"https://researchmap.jp/read0020501"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Matsumoto, Kayo","creatorNameLang":"en"},{"creatorName":"マツモト, カヨ","creatorNameLang":"ja-Kana"},{"creatorName":"松元, 圭代","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Kiyomoto Co., Ltd.","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Omura, Ayano","creatorNameLang":"en"},{"creatorName":"オオムラ, アヤノ","creatorNameLang":"ja-Kana"},{"creatorName":"大村, 文乃","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Kiyomoto Co., Ltd.","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Kiyomoto, Kunio","creatorNameLang":"en"},{"creatorName":"キヨモト, クニオ","creatorNameLang":"ja-Kana"},{"creatorName":"清本, 邦夫","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Osaka City University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Kojima-Yuasa, Akiko","creatorNameLang":"en"},{"creatorName":"ユアサ(コジマ), アキコ","creatorNameLang":"ja-Kana"},{"creatorName":"湯浅(小島), 明子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1000090295709","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000090295709"},{"nameIdentifier":"0000-0001-8167-3693","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0001-8167-3693"}]}]},"item_1617186499011":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"クリエイティブ・コモンズ　表示 - 非営利 - 改変禁止 4.0 国際 ","subitem_rights_language":"ja","subitem_rights_resource":"https://creativecommons.org/licenses/by-nc-nd/4.0/ "},{"subitem_rights":"Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International ","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by-nc-nd/4.0/ "},{"subitem_rights":"© 2020 Published by Elsevier Ltd.","subitem_rights_language":"en"}]},"item_1617186609386":{"attribute_name":"主題","attribute_value_mlt":[{"subitem_subject":"酸化ストレス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"脱脂ゴマ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"セサミノール","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"パーキンソン病","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ロテノン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Neuroscience","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Nutrition","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Natural product","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Oxidative stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Antioxidant","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Sesaminol","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Parkinson's disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"6-Hydroxydopamine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rotenone","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"SH-SY5Y cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Nrf2","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究グループは、産業廃棄物として処理される脱脂ゴマから精製されたセサミノールが、パーキンソン病予防効果を有することを細胞レベルおよび動物レベルでのパーキンソン病疾患モデルを用いて解明しました。まず、細胞を使った実験において、セサミノールが酸化ストレス応答に関与する転写因子Nrf2の核内移行を促進し、細胞内活性酸素種産生量を減少させることによって、6-hydroxydopamine(6-OHDA)誘導性神経細胞障害に対する保護効果を有することを明らかにしました。次に、ロテノン(マウスに投与するとパーキンソン病発症の原因となる)を経口投与することによって作製したin vivo パーキンソン病モデルマウスにセサミノールを含む試験食を36 日間摂食させて、ローターロッド試験により運動能力および腸管運動機能を測定したところ、ロテノンにより有意に低下した運動能力および腸管運動機能が、セサミノールによって有意に改善することが明らかになりました。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Parkinson's disease (PD) is a neurodegenerative disease caused by the degeneration of substantia nigra neurons due to oxidative stress. Sesaminol has strong antioxidant and anti-cancer effects. We investigated the preventive effect on PD as a new physiological action of sesaminol produced from sesaminol glycoside using in vitro and in vivo PD models....","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"This work was supported by Japan Society for the Promotion of Science(JSPAS) KAKENHI, Grant Number, JP15K00832.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_1617186783814":{"attribute_name":"識別子","attribute_value_mlt":[{"subitem_identifier_type":"DOI","subitem_identifier_uri":"https://doi.org/10.1016/j.heliyon.2020.e05342"}]},"item_1617186920753":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"2405-8440","subitem_source_identifier_type":"ISSN"}]},"item_1617187056579":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-11-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageStart":"e05342","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"Heliyon","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1722232185104":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-02-08"}],"displaytype":"detail","filename":"24058440-6-11-e05342.pdf","filesize":[{"value":"2.7 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://ocu-omu.repo.nii.ac.jp/record/2019872/files/24058440-6-11-e05342.pdf"},"version_id":"6b45a0c0-7e3f-4be1-88c8-59b7706d6373"}]},"item_1722577087681":{"attribute_name":"記事種別等","attribute_value_mlt":[{"subitem_description":"Research article","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_1725590125188":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_title":"Sesaminol prevents Parkinson's disease by activating the Nrf2-ARE signaling pathway","item_type_id":"40002","owner":"7","path":["1721355153493"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-02-08"},"publish_date":"2021-02-08","publish_status":"0","recid":"2019872","relation_version_is_last":true,"title":["Sesaminol prevents Parkinson's disease by activating the Nrf2-ARE signaling pathway"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-31T01:20:45.317803+00:00"}