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This is a pre-copyedited, author-produced version of an article accepted for publication in Carcinogenesis following peer review. The version of record is available online at: https://doi.org/10.1093/carcin/bgaa031.","subitem_rights_language":"en"}]},"item_1617186609386":{"attribute_name":"主題","attribute_value_mlt":[{"subitem_subject":"STK11","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"LKB1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"スキルス胃癌","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"原因遺伝子","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"分子標的治療剤","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"STK11","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"LKB1","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究グループは、スキルス胃癌の原因変異遺伝子としてSTK11/LKB1を同定し、スキルス胃癌治療薬としてSTK11/LKB1関連シグナル系を制御するラパマイシンが有用であることを明らかにしました。スキルス胃癌は、急速に増殖進展し、高頻度に転移する極めて難治性の癌とされています。しかし、これまでその原因遺伝子や治療標的分子は十分に解明されていませんでした。今回、同研究チームは、附属病院で樹立したスキルス胃癌細胞株6株を用いて遺伝子解析を試みたところ、6株中3株に癌抑制遺伝子STK11/LKB1の変異を同定しました。さらにサンガ―シークエンス法で同遺伝子の変異を確認すると、STK11/LKB1変異型スキルス胃癌細胞ではSTK11/LKB1蛋白質の発現減弱や機能喪失も確認されました。これを受けて、胃癌細胞株にSTK11/LKB1関連シグナル系を制御するラパマイシンを作用させたところ、スキルス胃癌細胞の増殖が抑制されました。スキルス胃癌における原因遺伝子と治療標的分子を解明した世界初の研究であり、この研究成果によって、スキルス胃癌の治療が大きく前進すると考えられます。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Scirrhous-type gastric carcinoma (SGC), which is characterized by the rapid proliferation of cancer cells accompanied by extensive fibrosis, shows extremely poor survival. A reason for the poor prognosis of SGC is that the driver gene responsible for SGC has not been identified. To identify the characteristic driver gene of SGC, we examined the genomic landscape of six human SGC cell lines of OCUM-1, OCUM-2M, OCUM-8, OCUM-9, OCUM-12 and OCUM-14, using multiplex gene panel testing by next-generation sequencing. In this study,...","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"KAKENHI (Grant-in-Aid for Scientific Research, Nos. 18H02883 to M.Y.)","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Oxford University Press","subitem_publisher_language":"en"}]},"item_1617186783814":{"attribute_name":"識別子","attribute_value_mlt":[{"subitem_identifier_type":"DOI","subitem_identifier_uri":"https://doi.org/10.1093/carcin/bgaa031"}]},"item_1617186920753":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"1460-2180","subitem_source_identifier_type":"ISSN"}]},"item_1617187056579":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"1623","bibliographicPageStart":"1616","bibliographicVolumeNumber":"41","bibliographic_titles":[{"bibliographic_title":"Carcinogenesis","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_b1a7d7d4d402bcce","subitem_version_type":"AO"}]},"item_1617353299429":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1093/carcin/bgaa031","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"AA12072343","subitem_relation_type_select":"NCID"}}]},"item_1722232185104":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-02"}],"displaytype":"detail","filename":"14602180-41-11-1616.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://ocu-omu.repo.nii.ac.jp/record/2019700/files/14602180-41-11-1616.pdf"},"version_id":"d5362478-1ac1-44fa-b532-33a894ec0fd1"}]},"item_1725590125188":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_title":"Serine Threonine Kinase 11/Liver Kinase B1 Mutation in Sporadic Scirrhous-type Gastric Cancer Cells","item_type_id":"40002","owner":"7","path":["1721355153493"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-04-02"},"publish_date":"2021-04-02","publish_status":"0","recid":"2019700","relation_version_is_last":true,"title":["Serine Threonine Kinase 11/Liver Kinase B1 Mutation in Sporadic Scirrhous-type Gastric Cancer Cells"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-31T01:00:18.247798+00:00"}